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Edgars Liepinsh Selected Research

3-(2,2,2-trimethylhydrazine)propionate

12/2021Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.
11/2016Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
1/2014Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.
6/2012The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
9/2011Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats.
5/2011Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.
1/2011Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
9/2010Mildronate exerts acute anticonvulsant and antihypnotic effects.
8/2009Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
8/2009Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
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Edgars Liepinsh Research Topics

Disease

8Infarction (Infarctions)
12/2021 - 12/2006
7Insulin Resistance
03/2022 - 11/2016
7Ischemia
01/2021 - 08/2002
7Type 2 Diabetes Mellitus (MODY)
12/2020 - 08/2009
5Myocardial Infarction
01/2021 - 08/2009
4Inflammation (Inflammations)
12/2021 - 12/2005
4Hyperglycemia
01/2021 - 05/2011
4Atherosclerosis
11/2016 - 01/2009
4Encephalitis (Encephalitis, Rasmussen)
04/2010 - 12/2005
3Reperfusion Injury
01/2021 - 08/2009
3Cardiovascular Diseases (Cardiovascular Disease)
02/2017 - 11/2014
3Diabetes Complications
05/2012 - 08/2009
2Pyelonephritis
11/2021 - 03/2020
2Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2021 - 01/2017
2Hypoxia (Hypoxemia)
01/2021 - 01/2014
2Mitochondrial Diseases (Mitochondrial Disease)
12/2020 - 02/2017
2Heart Failure
12/2020 - 11/2016
2Hyperlipidemias (Hyperlipidemia)
12/2020 - 05/2011
2Glucose Intolerance
09/2017 - 05/2011
2Body Weight (Weight, Body)
01/2017 - 12/2007
2Weight Gain
01/2017 - 05/2011
2Obesity
01/2017 - 05/2011
2Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
11/2016 - 09/2011
2Brain Ischemia (Cerebral Ischemia)
11/2016 - 09/2011
2Cardiac Arrhythmias (Arrythmia)
11/2016 - 08/2009
2Atherosclerotic Plaque (Atheroma)
09/2015 - 01/2009
2Hypertension (High Blood Pressure)
01/2014 - 01/2011
2Necrosis
04/2010 - 08/2009
2Pain (Aches)
08/2009 - 03/2008
1Pulmonary Hypertension
12/2021
1Left Ventricular Dysfunction
12/2021
1Ventricular Dysfunction
12/2021
1COVID-19
12/2021
1Hypertrophy
12/2021
1Urinary Tract Infections (Urinary Tract Infection)
11/2021
1Infections
11/2021
1Hydronephrosis
11/2020
1Acute Kidney Injury (Acute Renal Failure)
11/2020
1Stable Angina
11/2018
1Stroke (Strokes)
11/2016

Drug/Important Bio-Agent (IBA)

14Carnitine (L-Carnitine)FDA LinkGeneric
11/2020 - 12/2006
133-(2,2,2-trimethylhydrazine)propionateIBA
12/2021 - 08/2002
10Fatty Acids (Saturated Fatty Acids)IBA
01/2022 - 08/2009
9Glucose (Dextrose)FDA LinkGeneric
03/2022 - 08/2009
8acylcarnitineIBA
12/2021 - 09/2015
4Insulin (Novolin)FDA Link
06/2021 - 01/2014
4trimethyloxamine (trimethylamine N-oxide)IBA
01/2020 - 11/2014
3Pharmaceutical PreparationsIBA
12/2021 - 11/2020
3LipopolysaccharidesIBA
10/2020 - 12/2007
3methyl-gamma-butyrobetaineIBA
08/2017 - 09/2015
3Blood Glucose (Blood Sugar)IBA
01/2017 - 08/2009
3Nitric Oxide (Nitrogen Monoxide)FDA Link
04/2010 - 06/2006
3MelanocortinsIBA
06/2006 - 01/2004
2Pyruvic Acid (Pyruvate)IBA
01/2021 - 10/2020
2LipidsIBA
12/2020 - 01/2019
2Metformin (Glucophage)FDA LinkGeneric
01/2020 - 05/2011
2PalmitoylcarnitineIBA
09/2017 - 01/2016
24-amino-3-phenylbutyric acid (phenibut)IBA
11/2016 - 03/2008
2gamma-butyrobetaine (butyrobetaine)IBA
09/2015 - 12/2006
2Apolipoproteins E (ApoE)IBA
09/2015 - 01/2009
22- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
06/2013 - 06/2012
2EnzymesIBA
05/2013 - 03/2011
2SaltsIBA
01/2011 - 08/2009
2NF-kappa B (NF-kB)IBA
04/2010 - 12/2005
21- (3,4- dimethoxy- 2- - chlorobenzylideneamino)guanidineIBA
04/2010 - 08/2004
2Melanocortin Receptors (Melanocortin Receptor)IBA
12/2007 - 12/2005
2Peptides (Polypeptides)IBA
12/2005 - 01/2004
1C-PeptideIBA
03/2022
1Ketone BodiesIBA
03/2022
1Insulin-Like Growth Factor I (IGF-1)IBA
03/2022
1AminoglycosidesIBA
11/2021
1Anti-Bacterial Agents (Antibiotics)IBA
11/2021
1Gentamicins (Gentamicin)FDA LinkGeneric
11/2021
1Amikacin (A.M.K)FDA LinkGeneric
11/2021
1AminesIBA
11/2021
1apramycinIBA
11/2021
1NADPH Oxidase 2IBA
01/2021
1itaconic acidIBA
01/2021
1HexokinaseIBA
01/2021
1Succinate Dehydrogenase (Fumarate Reductase)IBA
01/2021
1Succinic Acid (Succinate)IBA
01/2021
1empagliflozinIBA
12/2020
1Sodium-Glucose Transporter 2 InhibitorsIBA
12/2020
1Sodium-Glucose Transport ProteinsIBA
12/2020
1Furosemide (Lasix)FDA LinkGeneric
11/2020
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
10/2020
1AMP-Activated Protein KinasesIBA
10/2020
14- hydroxy- 3- (4- (2- hydroxyphenyl)phenyl)- 6- oxo- 7H- thieno(2,3- b)pyridine- 5- carbonitrileIBA
10/2020
1NAB 739 peptideIBA
03/2020
1Polymyxins (Polymyxin)IBA
03/2020
1Polymyxin B (Aerosporin)FDA LinkGeneric
03/2020
1Nonesterified Fatty Acids (NEFA)IBA
01/2019
1S-phenylpiracetamIBA
01/2017
1LeptinIBA
01/2017
1Appetite Depressants (Anorectics)IBA
01/2017
1Neuroprotective AgentsIBA
11/2016
1BuffersIBA
01/2016
1EstersIBA
09/2015
1gamma-Butyrobetaine DioxygenaseIBA
07/2014

Therapy/Procedure

1Drug Therapy (Chemotherapy)
11/2020